LIMD1 (LIM domains containing 1)
نویسندگان
چکیده
منابع مشابه
Competition between LIM-binding domains.
LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional 'LIM code'. The proteins all contain a pair of close...
متن کاملLIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
In recent years there have been major advances with respect to the identification of the protein components and mechanisms of microRNA (miRNA) mediated silencing. However, the complete and precise repertoire of components and mechanism(s) of action remain to be fully elucidated. Herein we reveal the identification of a family of three LIM domain-containing proteins, LIMD1, Ajuba and WTIP (Ajuba...
متن کاملPCD1, a novel gene containing PDZ and LIM domains, is overexpressed in several human cancers.
In an effort to discover novel genes differentially expressed in human pancreatic cancer, we have identified a gene named PCD1 (pancreatic cancer derived) that is up-regulated in pancreatic dysplasia and cancer relative to normal pancreatic ductal epithelium. We cloned the full length (4572 bp) of this gene, which encodes a novel protein of 1064 amino acids containing a PDZ domain and a LIM dom...
متن کاملCryptosporidium parvum genes containing thrombospondin type 1 domains.
Cryptosporidium parvum is recognized as an enteropathogen of great worldwide medical and veterinary importance, yet understanding of its pathogenesis has been hampered in part by limited knowledge of the invasion machinery of this parasite. Recently, genes containing thrombospondin type 1 (TSP1) domains have been identified in several genera of apicomplexans, including thrombospondin-related ad...
متن کاملOrganizing motility: LIM domains, LPP, and smooth muscle migration.
Vascular smooth muscle cells (SMCs) acquire a highly specialized cytoskeleton during development that is organized for efficient transmission of contractile force. This SMC cytoskeleton must be extensively reorganized to support directed cell migrations that are required for repair of arterial injury. Particularly important in this reorganization process are adaptor proteins that mediate the as...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2012
ISSN: 1768-3262
DOI: 10.4267/2042/46049